Japan Develops the First Treatment to Regrow Human Teeth – Clinical Trials Underway

In a groundbreaking advancement in dental medicine, Japan has developed the world’s first treatment to naturally regrow human teeth. In September 2024, Japanese researchers officially began the first phase of clinical trials on a new drug designed to treat tooth loss. The initial phase lasted 11 months, and the second phase will involve testing on children.

Dr. Katsu Takahashi, head of the Department of Oral and Maxillofacial Surgery at Kitano Hospital and lead researcher of the study, expressed hope that this innovative treatment will not be limited to congenital tooth conditions. Instead, it may eventually be used by anyone who has lost teeth—regardless of age.

According to the research team, this revolutionary drug could provide a natural alternative to dentures and dental implants, potentially allowing people to grow replacement teeth on their own.

Unlike reptiles and some species of fish that can regenerate teeth multiple times, humans and most mammals are known to develop only two sets of teeth in a lifetime. However, Dr. Takahashi explained that dormant “third tooth buds” exist beneath the gums, and their activation could allow for a new set of teeth to grow.

Animal studies involving mice and ferrets have shown promising results. By inhibiting the USAG-1 protein, researchers were able to stimulate the growth of a third set of teeth. The team even released laboratory images showing fully regrown teeth in test animals.

This advancement marks a major milestone in regenerative dental therapy and brings hope to millions suffering from tooth loss.